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Brennan M.R. Spiegel
Eric Esrailian
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Gil Melmed
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Brennan M.R. Spiegel, MD, MSHS

Publications (76)
Brennan M.R. Spiegel

Dr. Spiegel is Assistant Professor of Medicine in the Division of Digestive Diseases, UCLA School of Medicine, and in the Division of Gastroenterology, VA Greater Los Angeles Health Care System.

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Publications by Brennan M.R. Spiegel

Title An evidence-based position statement on the management of irritable bowel syndrome. 
Author(s) American College of Gastroenterology Task Force on Irritable Bowel Syndrome, Brandt LJ, Chey WD, Foxx-Orenstein AE, Schiller LR, Schoenfeld PS, Spiegel BM, Talley NJ, Quigley EM. 
Publication Am J Gastroenterol. 2009 Jan 104 Suppl 1:S1-35.  
Article View/Download Article
Title An explicit quality indicator set for measurement of quality of care in patients with cirrhosis. 
Author(s) Kanwal F, Kramer J, Asch SM, El-Serag H, Spiegel BM, Edmundowicz S, Sanyal AJ, Dominitz JA, McQuaid KR, Martin P, Keeffe EB, Friedman LS, Ho SB, Durazo F, Bacon BR. 
Publication Clinical Gastroenterology and Hepatology. 2010 [Epub ahead of print] 
Article PDF Not Available
Title Asymptomatic pancreatic cysts: maximizing survival and quality of life using Markov-based clinical nomograms. 
Author(s) Weinberg B, Spiegel BMR, Tomlinson J, Farrel J 
Publication Gastroenterology. 2010 Feb 138(2):531-40.  
Article View/Download Article
Title Balancing Cardiovascular and GI Outcomes with Antiplatelet Therapy: A Cost-Effectiveness Analysis of Competing Strategies.  
Author(s) vanOijen M; Laheij RJF; Targownik LE; Jansen JBM; Jansen JBM, Verheugt FWA, Spiegel BMR 
Publication Manuscript in primary submission. 
Article PDF Not Available
Title Dialysis practices that distinguish top vs. bottom performing facilities by hemoglobin outcomes.  
Author(s) Spiegel BMR, Bolus R, Desai AA, Zagar P, Parker T, Moran J, Bolus S, Solomon MD, Khawar O, Gitlin M, Talley J, Nissenson A 
Publication Manuscript in primary submission. 
Article View/Download Article
Title Global outcome measure of Adequate Relief detects clinically meaningful improvement in pain and performs consistently across pain severity levels in Irritable Bowel Syndrome. 
Author(s) Ameen VZ, Health AT, Spiegel BMR, McSorley D, Chang L 
Publication Manuscript in primary submission 
Article PDF Not Available
Title Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS experts.  
Author(s) Spiegel BM, Farid M, Esrailian E, Talley J, Chang L. 
Publication American Journal of Gasteroenterology. 2010 105(4): 848-58. 
Article View/Download Article
Title Meta-analysis: do irritable bowel syndrome symptoms vary between men and women? 
Author(s) Adeyemo MA, Spiegel BM, Chang L. 
Publication Ailmentary Pharmacology & Therapeutics. 2010 doi: 10.1111/j.1365-2036.2010.04409.x. [Epub ahead of print] 
Article View/Download Article
Title Psychometric evaluation of endpoints in IBS randomized controlled trials: a Rome Foundation Working Group report.  
Author(s) Spiegel BMR, Camilleri M, Bolus R, Andresen V, Chey WD, Fehnel S, Mangel A, Talley NJ, Whiehead WE 
Publication Manuscript in secondary revision.  
Article PDF Not Available
Title The appropriateness of concomitant immunomodulators and anti-tumor necrosis factor agents for Crohn's disease: one size does not fit all. 
Author(s) Melmed GY, Spiegel BM, Bressler B, Cheifetz AS, Devlin SM, Harrell LE, Irving PM, Jones J, Kaplan GG, Kozuch PL, Velayos FS, Baidoo L, Sparrow MP, Siegel CA. 
Publication Clinical Gastroenterology and Hepatology. 2010 [Epub ahead of print] 
Article PDF Not Available
Title Adherence to best practice guidelines in dyspepsia: a survey comparing dyspepsia experts, community gastroenterologists, and primary care providers.  
Author(s) Spiegel BMR, Farid M, van Oijen MGH, Laine L, Howden CW, Esrailian E 
Publication Alimentary Pharmacology and Therapeutics 2009 (29):871-81 
Article View/Download Article
Title Controversies in Ulcerative Colitis: A National Survey Comparing Decision-Making of Experts versus Community Gastroenterologists.  
Author(s) Spiegel BMR, Ho W, Esrailian E, Targan S, Higgins P, Siegel C, Dubinsky M, Melmed G 
Publication Clinical Gastroenterology and Hepatology. 2009 
Article View/Download Article
Title Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF cohort. 
Author(s) Spiegel BMR, Harris L, Lucak S, Mayer E, Naliboff B, Bolus R, Esrailian E, Chey WD, Lembo A, Karsan H, Tillisch K, Dulai G, Talley J, Chang L 
Publication American Journal of Gastroenterology. 2009 [Epub ahead of print] 
Article PDF Not Available
Title Fewer Polyps Detected by Colonoscopy as the Day Progresses at a Veteran's Administration Teaching Hospital. 
Author(s) Michael Y. Chan, Hartley Cohen, Brennan M.R. Spiegel  
Publication Clinical Gastroenterology and Hepatology. 2009 (7) 11:1217-1223 
Article PDF Not Available
Title Health Related Quality of Life Predicts Mortality in Patients awaiting Liver Transplantation.  
Author(s) Kanwal F, Gralnek IM, Bolus R, Kim SJ, Spiegel BMR.  
Publication Clinical Gastroenterology and Hepatology 2009 [Epub ahead of print]  
Article PDF Not Available
Title Is there “cherry picking” in the ESRD program? Perceptions from a dialysis provider survey.  
Author(s) Desai A, Bolus R, Nissenson A, Chertow GM, Bolus S, Solomon M, Khawar O, Talley J, Spiegel BMR 
Publication Clinical Journal of the American Society of Nephrology (CJASN). 2009 (4):772-7  
Article View/Download Article
Title Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.  
Author(s) Ford AC, Spiegel BMR, Talley NJ, Moayyedi P 
Publication Clinical Gastroenterology and Hepatology. 2009 (7)12:1279-86 
Article PDF Not Available
Title The burden of IBS: looking at metrics. 
Author(s) Spiegel BM. 
Publication Curr Gastroenterol Rep. 2009 Aug 11(4):265-9. 
Article PDF Not Available
Title The relationship between laboratory-based outcomes and mortality in end-stage renal disease: a systematic review.  
Author(s) Desai A, Farid M, Singh I, van Oijen MGH, Esrailian E, Solomon MD, Spiegel BMR 
Publication Hemodialysis International. 2009; 13 (3): 347-59 
Article PDF Not Available
Title Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis.  
Author(s) Ford AC, Chey WD, Talley NJ, Malhotra A, Spiegel BM, Moayyedi P 
Publication Archrive of Internal Medicine. 2009 (169):651-8 
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Title Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors? 
Author(s) Spiegel BM, Chey WD, Chang L. 
Publication American Journal of Gastroenterology. 2008 103(12):2972-6. 
Article View/Download Article
Title Comparison of health-related quality of life between populations. 
Author(s) Slavenburg S, van Oijen MG, Spiegel BM. 
Publication Liver International. 2008 28(2):285-6 
Article PDF Not Available
Title Cost-Effectiveness Analysis of Behavioral Intervention to Improve Vaccination Compliance in Homeless Adults.  
Author(s) Greengold B, Nyamathi A, Kominski G, Hodge F, Singer M, Spiegel BMR 
Publication Vaccine. 2008;27:718-25 
Article View/Download Article
Title Efficacy of fibre, antispasmodics, and peppermint oil in irritable bowel syndrome: systematic review and meta-analysis.  
Author(s) Ford AC, Talley NJ, Spiegel BMR, Foxx-Orenstein A, Schiller L, Quigley EMM, Moayyedi P  
Publication British Medical Journal. 2008 (13);337.  
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Title Evaluating the process of care in non-variceal upper gastrointestinal hemorrhage: a survey of experts vs. non-expert gastroenterologists.  
Author(s) Esrailian E, Gralnek IM, Jensen D, Laine L, Dulai GS, Eisen G, Spiegel BMR 
Publication Alimentary Pharmacology & Therapeutics. 2008 (28):1199 
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Title Identifying “best practices” in dialysis care: results of a national survey and cognitive interviews of dialysis stakeholders.  
Author(s) Desai A, Bolus R, Nissenson A, Bolus S, Solomon M, Khawar O, Gitlin M, Talley J, Spiegel BMR 
Publication Clinical Journal of the American Society of Nephrology (CJASN). 2008; Apr 16 
Article View/Download Article
Title Predictors of patient-assessed illness severity in irritable bowel syndrome.  
Author(s) Spiegel BMR, Strickland A, Naliboff B, Mayer E, Chang L 
Publication American Journal of Gastroenterology. 2008 (Jun 30 – Epub ahead of print) 
Article View/Download Article
Title Prospective validation of the short form liver disease quality of life instrument (SF-LDQOL). 
Author(s) Kanwal F, Spiegel BMR, Hays RD, Bolus R, Kim SJ, Gralnek IM 
Publication Alimentary Pharmacology & Therpeutic. 2008;28:1088-101 
Article View/Download Article
Title The relationship between biomarkers and health related quality of life in end-stage renal disease: a systematic review. 
Author(s) Spiegel BMR, Melmed G, Robbins S, Esrailian E 
Publication Clinical Journal of the American Society of Nephrology (CJASN). 2008; Oct 1 
Article PDF Not Available
Title A letter a day keep the cancer away: improving colon cancer screening adherence with a mailed brochure 
Author(s) B Spiegel 
Publication In Press at Evidence-Based Gastroenterology 
Article PDF Not Available
Title Clinical relevance of adjuvant chemotherapy in glioblastoma multiforme: a meta-analysis of competing agents 
Author(s) Spiegel BMR, Esrailian E, Laine L, Chamberlain M 
Publication In Press at CNS Drugs 
Article PDF Not Available
Title Development and validation of a disease-targeted quality of life instrument in chronic hepatitis B: The hepatitis B quality of life instrument, version 1.0 
Author(s) Spiegel BM, Bolus R, Han S, Tong M, Esrailian E, Talley J, Tran T, Smith J, Karsan HA, Durazo F, Bacon B, Martin P, Younossi Z, Hwa-Ong S, Kanwal F. 
Publication Hepatology. 2007 Jul;46(1):113-21. 
Article PDF Not Available
Title Differences in the management of Crohn's disease among experts and community providers, based on a national survey of sample case vignettes.  
Author(s) Esrailian E, Spiegel BMR, Targownik L, Dulai GS, Gralnek IM 
Publication Alimentary Pharmacological & Therapeutics. 2007(26):1005-18 
Article View/Download Article
Title Do physicians follow evidence-based guidelines in the diagnostic work-up of IBS? 
Author(s) Spiegel BM. 
Publication Nat Clin Pract Gastroenterol Hepatol. 
Article PDF Not Available
Title Functional GI disorders: From animal models to drug development. 
Author(s) Mayer EA, Bradesi S, Chang L, Spiegel BMR, Bueller JA, Naliboff BD 
Publication Gut 2007 
Article View/Download Article
Title Predictors of treatment in patients with chronic hepatitis C virus infection—Role of patient versus non-patient factors.  
Author(s) Kanwal F, Hoang T, Spiegel BMR, Dominitz J, Goetz M, Gifford A, Asch S 
Publication Hepatology. 2007 (46):1741-9  
Article View/Download Article
Title Systematic review: the prevalence of suicidal behaviour in patients with chronic abdominal pain and irritable bowel syndrome. 
Author(s) Spiegel B, Schoenfeld P, Naliboff B. 
Publication Aliment Pharmacol Ther. 2007 Jul;26(2):183-193. 
Article View/Download Article
Title The budget impact of screening for esophageal varices in cirrhosis. 
Author(s) Spiegel BMR, Esrailian E, Eisen G. 
Publication In Press at Gastrointestinal Endoscopy 
Article PDF Not Available
Title The cost-effectiveness of competing therapies for hepatic encephalopathy: a decision analysis. 
Author(s) Huang E, Esrailian E, Spiegel BMR 
Publication Alimentary Pharmacology and Therapeutics. 2007(26):1147-61 
Article View/Download Article
Title Comparing rates of dyspepsia with coxib versus NSAID+PPI combination therapy: a systematic review and meta-analysis. 
Author(s) Spiegel BMR, Farid M, Gralnek IM, Dulai GS, Kanwal F. 
Publication American Journal of Medicine 2006; 119(5):448.e27-36 
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Title Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials. 
Author(s) Gralnek IM, Dulai GS, Fennerty MB, Spiegel BM. 
Publication Clin Gastroenterol Hepatol. 2006 Dec;4(12):1452-8. 
Article View/Download Article
Title The cost-effectiveness and budget impact of intravenous versus oral proton pump inhibitors in peptic ulcer hemorrhage. 
Author(s) Spiegel BMR, Lim B, Mann N, Dulai GS, Gralnek IM. 
Publication Clinical Gastroenterology and Hepatology. 2006 Aug;4(8):988-997. Epub 2006 Jul 17. 
Article PDF Not Available
Title The cost-effectiveness of colonic stenting as a bridge to curative surgery in patients with acute left-sided malignant colonic obstruction: a Canadian perspective. 
Author(s) Singh H, Latosinsky S, Spiegel BM, Targownik LE. 
Publication Can J Gastroenterol. 2006 Dec;20(12):779-85. 
Article View/Download Article
Title The effectiveness of esomeprazole in erosive esophagitis: a metaanalysis. 
Author(s) Gralnek IM, Fennerty B, Spiegel BMR. 
Publication Manuscript in press at Clinical Gastroenterology and Hepatology 
Article PDF Not Available
Title Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysis. 
Author(s) Kanwal F, Farid M, Gralnek IM, Dulai G, Martin P, Chen G, Spiegel BMR. 
Publication American Journal of Gastroenterology;2006;10:2076-89 
Article View/Download Article
Title Budget Impact of Tegaserod on a Managed Care Organization Formulary. 
Author(s) Bloom M, Barghout V, Kahler K, Bentkover J, Kurth H, Gralnek IM, Spiegel BMR. 
Publication American Journal of Managed Care 2005;11:S27-S34 
Article View/Download Article
Title Combination endoscopic band ligation and sclerotherapy compared with endoscopic band ligation alone for the secondary prophylaxis of esophageal variceal hemorrhage: a meta-analysis. 
Author(s) Karsan HA, Morton SC, Shekelle PG, Suttorp MJ, Spiegel BMR, Edelstein MA, Shanman R, Gralnek IM. 
Publication Digestive Diseases and Sciences 2005;50:399-406 
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Title Erythropoietic Growth Factors for the management of treatment-related anemia in hepatitis C: clinical and economic consequences. 
Author(s) Spiegel BMR , Chen K, Broder M, Chiou Chiun-Fang. 
Publication Clinical Gastroenterology and Hepatology 2005;3:1034-42 
Article View/Download Article
Title Impact of chronic viral hepatitis on health related quality of life in HIV: results from a nationally representative sample. 
Author(s) Kanwal F, Gralnek IM, Hays RD, Spiegel BMR, Dulai GS, Bozzette S, Asch S. 
Publication Am J Gastroenterol 2005;100:1984-94 
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Title Is a negative colonoscopy associated with improved health-related quality of life or reassurance in irritable bowel syndrome? 
Author(s) Spiegel BMR, Gralnek IM, Bolus R, Mayer E, Chang L, Dulai GS, Naliboff B. 
Publication Gastrointestinal Endoscopy 2005;62:892-899 
Article View/Download Article
Title Is Wireless Capsule Endoscopy Appropriate for the Diagnosis and Management Of Crohn's Disease? A Survey Of North American Inflammatory Bowel Disease Experts' Disease 
Author(s) Esrailian E, Targownik LE, Spiegel BMR, Glassman PA, Dubinsky M, Targan SR, Gralnek IM. 
Publication Gastroenterology 2005;AB(DDW) 
Article PDF Not Available
Title Minimizing complications from nonsteroidal anti-inflammatory drugs: the cost-effectiveness of competing strategies in varying risk groups. 
Author(s) Spiegel BMR, Chiou CF, Ofman JJ. 
Publication Arthritis Care and Research 2005;15:185-97 
Article View/Download Article
Title North American Inflammatory Bowel Disease (IBD) Experts Reveal Extreme Variation in Their Process Of Care in Crohn's Disease 
Author(s) Esrailian E, Targownik LE, Spiegel BMR, Glassman PA, Dubinsky M, Targan SR, Gralnek IM. 
Publication Gastroenterology 2005;AB(DDW) 
Article PDF Not Available
Title Peptic ulcer disease and stress-related mucosal disease 
Author(s) Spiegel BMR, Dulai GS. 
Publication Hospital Medicine; 2d ed. [Book]. 
Article PDF Not Available
Title PPI therapy in nonulcer dyspepsia: still working after all these years. 
Author(s) Spiegel BMR, Dulai GS. 
Publication Evidence-Based Gastroenterology 2005 
Article PDF Not Available
Title Recipient Characteristics and Post-Liver Transplantation Outcomes Before and After MELD. 
Author(s) Kanwal F, Dulai GS, Spiegel BMR, Yee HF, Gralnek IM. 
Publication Alimentary Pharmacology and Therapeutics 2005;15;21:169-77 
Article View/Download Article
Title The impact of hepatitis C on health related quality of life: a systematic review of the literature. 
Author(s) Spiegel BMR , Younossi ZM, Hays RD, Revicki D, Robbins S, Kanwal F. 
Publication Hepatology 2005;41:790-800 
Article View/Download Article
Title The impact of somatization on gastrointestinal health resource use in irritable bowel syndrome. 
Author(s) Spiegel BMR, Kanwal F, Naliboff B, Mayer E. 
Publication American Journal of Gastroenterology 2005;100:2262-73 
Article View/Download Article
Title Traditional Chinese medicine based subgrouping of irritable bowel syndrome patients. 
Author(s) Tan S, Tillisch K, Bolus R, Olivas T, Naliboff L, Chang L, Spiegel BMR, Mayer EA S. 
Publication Am J Chin Med. 2005;33(3):365-79 
Article View/Download Article
Title Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis. 
Author(s) Kanwal F, Gralnek IM, Martin P, Dulai GS, Martin P, Spiegel BMR. 
Publication Annals of Internal Medicine 2005;142:821-31. 
Article View/Download Article
Title Clinical determinants of health-related quality of life in patients with irritable bowel syndrome. 
Author(s) Spiegel BMR, Gralnek IM, Mayer EB, Bolus R, Dulai GS, Chang L, Naliboff B. 
Publication Archives of Internal Medicine 2004;164:1773-1780 
Article View/Download Article
Title Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis. 
Author(s) Targownik LE, Spiegel BM, Sack J, Hines OJ, Dulai GS, Gralnek IM, Farrell JJ. 
Publication Gastrointest Endosc 2004;60(6):865-74. 
Article View/Download Article
Title How much do coxibs cost? 
Author(s) Spiegel BMR, Dulai GS 
Publication Evidence-Based Gastroenterology 2004;5:10-11 
Article PDF Not Available
Title Rethinking the safety of clopidogrel: lessons learned from ulcers in Asia. 
Author(s) Spiegel BMR, Dulai GS 
Publication Evidence-Based Gastroenterology 2004;5 
Article PDF Not Available
Title Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: A cost-effectiveness analysis. 
Author(s) Spiegel BMR, DeRosa VP, Wang V, Gralnek IM, Dulai GS. 
Publication Gastroenterology 2004;126(7):1721-32. 
Article View/Download Article
Title The cost-effectiveness of hepatic pressure gradient monitoring in the prevention of recurrent variceal hemorrhage. 
Author(s) Targownik LE, Spiegel BM, Dulai GS, Karsan HA, Gralnek IM. 
Publication American Journal of Gastroenterology 2004;99:1306-15 
Article View/Download Article
Title The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal. 
Author(s) Spiegel BMR, Targownik LE, DeRosa V, Dulai GS, Gralnek IM, Chiou CF. 
Publication Gastroenterology 2004;127:403-411 
Article View/Download Article
Title Carvedilol or propranolol for variceal prophylaxis: Unconfidence intervals confound the choice. 
Author(s) Spiegel BMR, Gralnek IM. 
Publication Evidence-Based Gastroenterology 2003;4:107-109 
Article PDF Not Available
Title Endoscopic screening for esophageal varices in cirrhosis: is it ever cost-effective? 
Author(s) Spiegel BMR, Targownik LE, Karsan HA, Dulai GS, Gralnek IM. 
Publication Hepatology 2003:37:366-77 
Article View/Download Article
Title Management of acute non-variceal upper gastrointestinal tract hemorrhage: comparison of a U.S. and a Canadian medical center. 
Author(s) Targownik LE, Gralnek IM, Dulai GS, Spiegel BMR, Oei T, Bernstein CN. 
Publication Canadian Journal of Gastroenterology 2003;17:489-95 
Article PDF Not Available
Title Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost-effectiveness of competing strategies. 
Author(s) Spiegel BMR, Ofman JJ, Vakil NB. 
Publication Am J of Gastroenterology 2003;98:86-97 
Article View/Download Article
Title The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis. 
Author(s) Spiegel BMR, Targownik LE, Dulai GS, Gralnek IM. 
Publication Ann Int Med 2003;138:795-806 
Article View/Download Article
Title Dyspepsia management in primary care: a decision analysis of competing strategies. 
Author(s) Spiegel BMR, Vakil NB, Ofman JJ. 
Publication Gastroenterology 2002;122:1270-1285 
Article View/Download Article
Title Early medical therapy reduces intra-gastric blood in upper gastrointestinal tract hemorrhage: a difference that makes a difference? 
Author(s) Spiegel BMR, Gralnek IM. 
Publication Evidence-Based Gastroenterology 2002;3:40-41 
Article PDF Not Available
Title The impact of negative diagnostic tests in the management of non-ulcer dyspepsia: is no news good news? 
Author(s) Spiegel BMR 
Publication Evidence-Based Gastroenterology 2002;3:47-48 
Article PDF Not Available
Title Endoscopy for acute non-variceal upper gastrointestinal tract hemorrhage: is sooner better? A systematic review. 
Author(s) Spiegel BMR, Vakil NB, Ofman JJ. 
Publication Archives of Internal Medicine 2001;161:1393-1404 
Article View/Download Article
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