Systematic Review and Meta-Analysis
Members of the Center have extensive experience in conducting systematic reviews and meta-analyses of medical literature across a broad range of clinical problems. Center investigators have expertise in performing targeted literature searches, developing data-abstraction protocols, compiling evidence tables, applying standardized quality scales, and calculating pooled estimates using a range of meta-analysis techniques. Examples of research performed at the Center include a systematic review of the effectiveness of early endoscopy in acute upper gastrointestinal tract hemorrhage, a meta-analysis of cancer risk in Barrett's esophagus, and a comparison of adverse reactions between COX-2 inhibitors and generic anti-inflammatory medications.
Members of the Center work with investigators to evaluate whether specific clinical questions may be answered with systematic review/meta-analysis, help refine questions so they are amenable to this technique, and assist in the rapid conduct and write-up of high quality analyses.